Macrophages, monocytic THP-1 cells (low staining: Jurkat T cells, coronary artery smooth muscle cells, umbilical vein endothelial cells)Įpidermis, normal epidermal keratinocytes, immortalized keratinocyte cell line (HaCaT) Both pertussis toxin-sensitive and -insensitive G-proteins have been implicated in phospholipase C activation through GPR132. GPR132 has been proposed to signal through Gα 13 and Gα s. Lysophosphatidylcholine inhibited the pH-dependent activation of GPR132 in a dose dependent manner. GPR4, GPR65, GPR68 and GPR132 are now thought to function as proton-sensing receptors detecting acidic pH. ![]() GPR132 has been reported to be activated by lysophosphatidylserine, by oxidized free fatty acids produced by oxidation and subsequent hydrolysis of phosphatidylcholine or cholesteryl linoleate A report that the receptor was activated by lysophosphatidylcholine was later retracted. NP_037477 (Hs), NP_064309 (Mm), NP_001164066 (Rn)ĭownload all structure-activity data for this target as a CSV file Agonists
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